Oxidative stress response pathways: Fission yeast as archetype

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Oxidative stress response pathways: Fission yeast as archetype.

Schizosaccharomyces pombe is a popular model eukaryotic organism to study diverse aspects of mammalian biology, including responses to cellular stress triggered by redox imbalances within its compartments. The review considers the current knowledge on the signaling pathways that govern the transcriptional response of fission yeast cells to elevated levels of hydrogen peroxide. Particular attent...

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role of oxidative stress response and trehalose accumulation in the longevity of fission yeast

conclusions our results demonstrated no significant correlation between the ird5 lifespan and the trehalose concentration. likewise, the correlation between lifespan extension, trehalose accumulation, and cellular resistance to hydrogen peroxide was not significant. results the lifespan of the ird5 mutant was significantly longer that of either the ird11 mutant or the wild type cells. under rep...

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Yeast oxidative stress response

Aerobic organisms are constantly exposed to reactive oxygen species (ROS), generated as normal metabolism byproducts, especially by respiration [1,2]. To modulate ROS concentrations and to counteract their deleterious effects, there are several antioxidant systems with an apparent functional redundancy, which may provide an evolutionary advantage. Saccharomyces cerevisiae cells possess multiple...

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Genes involved in glucose repression and oxidative stress response in the fission yeast Schizosaccharomyces pombe.

We looked for changes in gene expression and novel genes that could be involved in the interaction between glucose repression and oxidative stress response in the fission yeast, Schizosaccharomyces pombe, using a constitutive invertase mutant, ird11, which is resistant to glucose. BLAST analysis was made of the S. pombe genome database of cDNAs whose expression ratios differentially decrea...

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Role of Oxidative Stress Response and Trehalose Accumulation in the Longevity of Fission Yeast

BACKGROUND Glucose is the preferred carbon and energy source in most organisms and plays an active role in the regulation of many biological processes. However, an excess of glucose leads to such undesirable conditions as diabetes and age-related diseases. Since Schizosaccharomyces pombe homologous of many human genes, it offers several advantages for the investigation of the molecular mechanis...

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ژورنال

عنوان ژورنال: Critical Reviews in Microbiology

سال: 2015

ISSN: 1040-841X,1549-7828

DOI: 10.3109/1040841x.2013.870968